Figure 1From: Stem cells and cancer immunotherapy: Arrowhead’s 2nd annual cancer immunotherapy conference Target characteristics and corresponding therapeutic approaches. This diagram outlines the major desirable characteristics of new targets for immune interventions. Depending on expression pattern, such targets fall into two categories: 1) with membrane expression and thus targetable by antibodies, antibody drug conjugates, bispecific antibodies/constructs, CAR-engineered T cells and certain vaccines that induce antibodies; and 2) expressed inside the cells, and thus amenable to vaccines, tumor infiltrating lymphocytes, small molecules, re-programmed T cells and NKT cells.Back to article page