Volume 2 Supplement 1

Abstracts of the Updates on Immunotherapy of Cancer and Immunoscore Symposium: Abstracts (Sidra Symposia Series)

Open Access

Proteomics approaches towards early detection and diagnosis of ovarian cancer

  • Ali Tiss1,
  • John Timms2,
  • Usha Menon2,
  • Alex Gammerman3 and
  • Rainer Cramer4
Journal for ImmunoTherapy of Cancer20142(Suppl 1):O5

DOI: 10.1186/2051-1426-2-S1-O5

Published: 24 February 2014

Early stage detection of cancer is the key to provide a better outcome for therapeutic intervention. Proteomic technologies hold recently great promise in the search of new clinical biomarkers for the early detection and diagnosis of cancer or for the development of new vaccines.

In this perspective, we will present our recent work in improving early diagnosis of ovarian cancer (OC) by combining MS analysis of serum peptidome with data collected over a period of 7 years from the United Kingdom Collaborative Trial of Ovarian Cancer Screening. Using 295 patients with OC, 290 with benign neoplasm, and 2236 postmenopausal healthy controls, our results showed that OC could be accurately predicted up to 15 months before its clinical diagnosis, based a combination of two MS peaks with CA125 clinical test. An overall sensitivity of 94.8% (96.6% specificity) was obtained when comparing malignancies versus healthy postmenopausal controls. High classification accuracies were also obtained for early-stage cancers (93.5% sensitivity). MS discriminatory peaks were identified as connective tissue-activating peptide III (CTAPIII) and platelet factor 4 (PF4), platelet-derived chemokines, suggesting a link between platelet function and tumour development. Those markers might be promising for clinical use in cancer early detection and treatment.

Authors’ Affiliations

(1)
Dasman Institute, Biochemistry & Molecular Biology Unit, Dasman Institute
(2)
EGA Institute for Women’s Health, Proteomics Unit, University College London
(3)
Royal Holloway University of London, Computer Learning Research Centre, Royal Holloway, University of London
(4)
University of Reading, Department of Chemistry, University of Reading

Copyright

© Tiss et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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