Volume 2 Supplement 3
Patterns of long-term survival following Ipilimumab (Ipi): the Memorial Sloan Kettering Cancer Center 10-year metastatic melanoma (MM) experience
© Page et al.; licensee BioMed Central Ltd. 2014
Published: 6 November 2014
Through a search of institutional databases, we identified 766 pts with MM treated with Ipi between 1/1/2003 and 12/31/2013. As of 4/1/2014, 96 pts have survived ≥2 yrs, measured from first dose of Ipi. OS was calculated utilizing the Kaplan-Meier method. Disease control was defined as the duration from initiation of Tx until initiation of subsequent systemic Tx or death.
Pts receiving locoregional Tx at first progression.
# pts achieving ≥1yr
CNS, surgery and/or RT
Post-Ipi Systemic Txs.
# pts achieving ≥1yr disease control*
Other clinical trial
Within this single-institution cohort, the median OS and 2-yr OS were greater than reported previously in Phase III trials [1, 2]. Potential reasons for this survival advantage include: referral bias, heterogeneous Ipi dosing/schedule, and access to subsequent trials (i.e. anti-PD-1/PD-L1, BRAF inhibitor). The majority of long-term survivors required subsequent Tx, however prolonged disease control was achieved with a range of Tx's. Pts who experience oligometastatic/CNS-only progression following Ipi may achieve prolonged disease control with locoregional Tx alone.
- Hodi F, O'Day S, McDermott D: Improved Survival with Ipilimumab in patients with metastatic melanoma. N Engl J Med. 363: 711-23.
- Robert C, Thomas L, Bondarenko I: Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 364: 2517-26.
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