Figure 1

Demonstration of changes in AST/ALT values over time with administration of ipilimumab; AST and ALT levels were measured weekly during the administration of ipilimumab. Sixteen weeks following initial induction, AST and ALT levels peaked at Grade 3. Resolution to Grade 1 was seen at Week 20, and monthly monitoring of liver function tests has been performed since, with continued evidence of stability. Arrows denote the times of administration of ipilimumab.