Fig. 12

(Abstract O11). Inhibition Wnt5a-DC FAO Enhances Melanoma PD-L1 Expression and Augments anti-PD-1 antibody Efficacy. A. Schematic of Wnt5a paracrine signaling pathway. B,C. Genetic silencing of Wnt5a in melanoma promotes T cell infiltration and PD-L1 upregulation. D. Inhibition of CPT1A/FAO synergizes with anti-PD-1 antibody therapy in melanoma