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Fig. 27 | Journal for ImmunoTherapy of Cancer

Fig. 27

From: 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

Fig. 27

(Abstract P23). Timelapse of a CAR19 macrophage (mRFP+) phagocytosing a CD19+ K562 cells (GFP+) cell (A). CARMA but not Wt macrophages phagocytosed CD19+ but not CD19- tumor cells (B). Phagocytosis was confirmed by Imagestream cytometry, gating on mRFP+GFP+ events (C). Blockade of CD47 and SIRPa led to a dose dependent increase in CARMA phagocytosis. Non-blocking anti-CD47 clone 2D3 (opsonization control) did not enhance phagocytosis (D)

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