Fig. 58

(Abstract P126). MCLA-117 efficiently induced T cell expansion and redirected lysis of AML blast in primary AML samples even at a low E:T ratio. Primary AML blast sample taken at diagnosis was incubated with MCLA-117 and a control Biclonics (binding CD3 and an irelevant antigen). CLEC12A expression, T cell proliferation and primary AML blast lysis was quantified using flow cytometry