Fig. 41 (abstract P323).

Immunotherapy impact on tumor growth in vivo. a Representative BLI images at day 1, 3 and 7 after immunotherapy for all 3 groups. Signals are expressed in radiance (p/sec/cm2/sr) b Time course of bioluminescence intensity in treated and untreated groups. CAR-T cell treated animals display a radiance half as high as untransduced-T cell treated animals or untreated animals. C. Corresponding tumor volumes show 50% reduction in tumor growth for the CAR-T cell treated group (p=0.0001) and no significant difference between untransduced T cell treated and untreated groups (p=0.38)