Fig. 54 (abstract P339).

Innate immune sensing of MVA∆E3L virus in cDCs. Shown here is a series of bar graphs showing that cGAS is required for the induction of type I IFN by MVA∆E3L in cDCs. a Bar graphs showing mRNA levels of IFNA4 and IFNB in cGAS+/+ and cGAS−/− cDCs infected with MVA∆E3L. b Bar graphs showing IFN-α and IFN-β secretion levels in cGAS+/+ and cGAS−/− cDCs infected with MVA∆E3L or treated with cGAMP, an agonist for STING. c A scanned image of an immunoblot showing protein levels of p-IRF3 and GAPDH in cGAS+/+ and cGAS−/− cDCs infected with MVA∆E3L