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Fig. 61 (abstract P360). | Journal for ImmunoTherapy of Cancer

Fig. 61 (abstract P360).

From: 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Fig. 61 (abstract P360).

The combination of BiVax with IL-2cx induced a robust amount of endogenous TR-CTLs. a C57BL/6 mice were immunized with BiVax on day 0 and 12. IL-2 complexCD122 or IL-2 complexCD25 was administered on day 12, 14, and 16 in the indicated group. The percentage of (TAPDNLGYM) Trp1-tetramer+ cells in blood CD8+ T cells was examined on day 19 (boost). Images of the representative results on day 19 are shown. b On day 19, the number of Trp1-tetramer+ cells in spleen was examined. c Purified CD8+ T cells from vaccinated mice were used in ELISpot assay. T cells were cultured with B16F10 melanoma cells for overnight. Results are presented as mean ± SD. (*p<0.05, n.s.: not significant)

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