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Fig. 75 (abstract P382). | Journal for ImmunoTherapy of Cancer

Fig. 75 (abstract P382).

From: 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Fig. 75 (abstract P382).

Features of exhaustion were detected on NK cells isolated from fresh melanoma donor (MD) blood. NK cells from MD show reduced cytotoxicity capacity (expression of LAMP-1/CD107a in response to co-culture with K562 cells), IFN-γ production in response to IL-12, and proliferation after IL-2 stimulation, compared with NK cells isolated from fresh healthy donor (HD) blood. These reduced functional properties are consistent with the concept that advanced disease is progressively associated with systemic immune suppression

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