Table 1 Demographics of patients in the discovery and validation populations
Discovery data set | Validation data set | |
|---|---|---|
Number of patients | 210 | 150 |
Age, median (range) years | 59 (22–90) | 53 (18–89) |
Gender n (%) | ||
Male | 117 (56%) | 94 (63%) |
Female | 93 (44%) | 56 (37%) |
Objective Response n (%) | ||
Patient responsive | 28 (13%) | 20 (13%) |
Patients non-responsive | 182 (87%) | 130 (87%) |
One-year Survival n (%) | ||
Patient alive at one year | 118 (56%) | 43 (29%) |
Patient deceased at one year | 92 (44%) | 107 (71%) |
Prior chemotherapy | No | Yes |
Stage of disease n (%) | ||
IIIC | 13 (6%) | 5 (3%) |
IV M1A | 35 (17%) | 16 (11%) |
IV M1B | 49 (23%) | 30 (20%) |
IV M1C | 113 (54%) | 99 (66%) |
Live in United States n (%) | ||
U.S. | 44 (21%) | 62 (41%) |
Non-U.S. | 166 (79%) | 88 (59%) |