15-Gene Pre-Treatment Model | Predictor or Enhancer Variable | Blood Bank | Difference Normals versus Responders | Phase 3 Discovery Dataset | ||
---|---|---|---|---|---|---|
N = 50 | N = 28 | N = 182 | Difference | |||
Healthy Normals | Responders | Non-Responders | Responders vs Non-responders | |||
Responders Equivalent to Normals | ||||||
ITGA4 | Predictor | 14.2 | 0.02 | 14.22 | 14.61 | 0.39 |
LARGE | Predictor | 22.0 | 0.09 | 22.09 | 22.97 | 0.88 |
CDK2 | Predictor | 19.6 | 0.09 | 19.69 | 19.91 | 0.22 |
TIMP1 | Enhancer | 15.0 | 0.10 | 15.1 | 14.95 | −0.15 |
DPP4 | Predictor | 18.5 | 0.12 | 18.62 | 18.95 | 0.33 |
NRAS | Predictor | 17.1 | 0.13 | 17.23 | 17.44 | 0.21 |
ERBB2 | Predictor | 23.0 | −0.18 | 22.82 | 23.23 | 0.41 |
NAB2 | Predictor | 20.0 | −0.29 | 19.71 | 20.04 | 0.33 |
Responders Upregulated Compared to Normals | ||||||
ADAM17 | Enhancer | 18.5 | 0.32 | 18.18 | 18.36 | 0.18 |
RHOC | Enhancer | 16.9 | 0.39 | 16.51 | 16.63 | 0.12 |
TGFB1 | Enhancer | 13.4 | 0.45 | 12.95 | 13.05 | 0.10 |
CDKN2A | Predictor | 21.4 | 0.63 | 20.77 | 21.16 | 0.39 |
Responders Downregulated Compared to Normals | ||||||
HLADRA | Enhancer | 12.1 | 0.48 | 12.58 | 12.64 | 0.06 |
MYC | Enhancer | 17.7 | 0.82 | 18.53 | 18.67 | 0.14 |
Measurement of Gene Expression Not Available | ||||||
ICOS | Predictor | N/A | N/A | 22.32 | 22.78 | 0.46 |