Figure 1

Graphical representation of MDSC inhibition strategies. (Abbreviations: NO – Nitric Oxide; PDE-5 – Phosphodiesterase 5; NO-Aspirin – Nitro-aspirin; L-Name – N(G)-Nitro-L-Arginine Methyl Ester; COX2 – Cyclooxygenase 2; CSF-1R – Colony Stimulating Factor Receptor 1; ATRA – All Trans Retinoic Acid; CpG – Deoxycytosine-Deoxyguanine Dinucleotide; JAK2 – Janus-Activated Kinase-2; STAT3 – Signal Transducer and Activator of Transcription 3; VEGF – Vascular Endothelial Growth Factor; 17-DMAG – 17-Dimethylaminoethylamino-17-Demethoxygeldanamycin; IL-6R – IL-6 Receptor); * – Agents that are presently under clinical investigation as MDSC inhibitors.