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Figure 1 | Journal for ImmunoTherapy of Cancer

Figure 1

From: Statistical issues and challenges in immuno-oncology

Figure 1

Graphical presentation of Kaplan-Meier survival curves with various combinations of long term survival and delayed clinical effect. The following plots show four hypothetical scenarios of overall survival outcome where the red and black curves represent novel immuno-oncologic agent and a control treatment respectively. (A) Conventional proportional hazards model with exponential assumption; (B) Proportional hazards model with long term survival; (C) Non-proportional hazards model with delay clinical effect; (D) Non-proportional hazards cure rate model with long term and delayed effects.

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