| PHM | PHCRM | NPHM | NPHCRM |
---|---|---|---|---|
Cure rate | – | 0.10 vs. 0.18 | – | 0.10 vs. 0.17 |
Delayed clinical effect (month) | – | – | 3 | 3 |
Sample size | 680 | 680 | 680 | 680 |
Number of events | 512 | 512 | 512 | 512 |
Hazard ratio (pre- and post- separation) | 0.75 | 0.75 | 1/0.75 | 1/0.75 |
Type I error | 0.05 | 0.05 | 0.05 | 0.05 |
Power | 0.90 | 0.90 | 0.70 | 0.70 |
Accrual duration (month) | 34 | 34 | 34 | 34 |
Study duration (month) | 48 | 55 | 47 | 54 |