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Table 2 Patients express multiple allelic variations of PAP and PSA genes

From: Presence of antigen-specific somatic allelic mutations and splice variants do not predict for immunological response to genetic vaccination

  

PAP allelic variants

PSA allelic variants

 
 

Patients

122T>G

849C>T

993T>C

1146A>G

48T>G

54A>C

84C>T

237C>T

304G>A

394C>A

536T>C

 

1

X

X

X

X

      

X

 

2

X

X

X

X

       
 

3

X

       

X

  
 

4

X

          
 

5

X

          
 

6

X

          

Non-Responders

7

 

X

X

X

       
 

8

 

X

X

X

       
 

9

        

X

  
 

10

           
 

11

           
 

12

           
 

13

 

X

X

X

       
 

14

           
 

15

           
 

16

  

X

X

       
 

17

 

X

X

X

  

X

    
 

18

  

X

X

       
 

19

 

X

X

X

   

X

 

X

 
 

20

  

X

X

       
 

21

  

X

X

      

X

 

22

           
 

23

 

X

 

X

   

X

 

X

 

Immune Responders

24

           
 

25

       

X

   
 

26

  

X

X

   

X

   
 

27

 

X

X

X

   

X

   
 

28

   

X

       
 

29

    

X

X

   

X

 
 

30

    

X

  

X

 

X

 
 

31

 

X

X

X

   

X

   
 

32

           
 

33

 

X

X

X

       
  1. Shown are individual SNPs detected among PAP-specific immune non-responding patients (top, 1–13) and PAP-specific immune responding patients (bottom, 14–33). Detected allelic variants are named for their relative position within each gene such that PAP-c.122T>G is the T→G transversion in the 122 nucleotide from the cDNA start site. Detection of an allelic variant is indicated by an X. Bold face indicates synonymous coding mutations and bold face italic indicates non-synonymous coding mutations.