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Table 3 mRNA transcripts of native and splice variants of PAP are detectable in pre-vaccination patient PBMC

From: Presence of antigen-specific somatic allelic mutations and splice variants do not predict for immunological response to genetic vaccination

  

PAP mRNA transcripts

  

Control mRNA transcripts

 

Patients

ACPP-001

ACPP-002

ACPP-003

ACPP-004

β-actin

KLK3-201

 

1

X

 

X

 

X

X

 

2

X

X

X

X

X

X

 

3

X

X

X

X

X

 
 

4

X

X

X

 

X

X

 

5

    

X

X

 

6

X

X

X

X

X

 

Non-Responders

7

X

X

X

 

X

 
 

8

X

 

X

 

X

X

 

10

  

X

 

X

X

 

11

X

X

X

X

X

X

 

12

X

 

X

X

X

X

 

13

    

X

 
 

14

X

X

X

 

X

X

 

15

X

 

X

X

X

X

 

16

X

 

X

 

X

X

 

17

X

X

X

X

X

X

 

18

X

 

X

 

X

X

 

19

X

X

X

 

X

X

 

24

X

   

X

X

Immune Responders

25

X

   

X

 
 

26

    

X

X

 

27

X

X

X

X

X

X

 

28

X

 

X

 

X

X

 

29

X

 

X

X

X

X

 

31

X

 

X

 

X

X

 

32

X

 

X

 

X

X

 

33

X

X

X

X

X

X

  1. Shown are native and alternative splice variant PAP products detected among immune non-responding patients (top, 1–13) and immune responding patients (bottom, 14–33). Detection of an mRNA transcript is indicated by an X.