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Table 1 A list of viral agents that should be tested in human cell lines used to manufacture cancer immunotherapeutic products

From: Regulation of immunotherapeutic products for cancer and FDA’s role in product development and clinical evaluation

Human Viruses:

Cytomegalovirus (CMV)

HIV-1 & 2

HTLV-1 & 2

Epstein-Barr Virus (EBV)

Hepatitis B Virus

Hepatitis C Virus

Human Parvovirus B19

Adenovirus

Adeno-Associated Virus (AAV)

 

Production cell medium/reagents Specific Viruses (e.g., Bovine and Porcine Viruses)