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Table 3 Grade 2 or greater toxicities associated with vaccine

From: A randomized pilot phase I study of modified carcinoembryonic antigen (CEA) peptide (CAP1-6D)/montanide/GM-CSF-vaccine in patients with pancreatic adenocarcinoma

  Grade 1 Grade 2 Grade 3 Grade 4
Toxicity No. (%) No. (%) No. (%) No. (%)
Injection-site reaction 11 (53) 1 (5) 0 (0) 0 (0)
 Erythema 9 (47)    
 Induration 6 (32) 1 (5)   
 Pain 3 (16)    
 Ecchymosis 2 (11)    
 Discoloration 1 (5)    
 Edema 1 (5)    
 Rash 1 (5)    
 Reaction NOS 1 (5)    
Toxicity unrelated to injection site 10 (53) 3 (16) 4 (21) 0 (0)
 Pain 10 (53) 3 (16) 2 (11)  
 Fatigue 10 (53) 1 (5) 4 (21)  
 Anorexia 4 (21) 0 (0) 2 (11)  
 Nausea/Vomiting 8 (42) 0 (0) 1 (5)  
 Constipation 6 (32) 2 (11) 1 (5)  
 Diarrhea 3 (16) 1 (5) 1 (5)