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Table 3 Grade 2 or greater toxicities associated with vaccine

From: A randomized pilot phase I study of modified carcinoembryonic antigen (CEA) peptide (CAP1-6D)/montanide/GM-CSF-vaccine in patients with pancreatic adenocarcinoma

 

Grade 1

Grade 2

Grade 3

Grade 4

Toxicity

No. (%)

No. (%)

No. (%)

No. (%)

Injection-site reaction

11 (53)

1 (5)

0 (0)

0 (0)

 Erythema

9 (47)

   

 Induration

6 (32)

1 (5)

  

 Pain

3 (16)

   

 Ecchymosis

2 (11)

   

 Discoloration

1 (5)

   

 Edema

1 (5)

   

 Rash

1 (5)

   

 Reaction NOS

1 (5)

   

Toxicity unrelated to injection site

10 (53)

3 (16)

4 (21)

0 (0)

 Pain

10 (53)

3 (16)

2 (11)

 

 Fatigue

10 (53)

1 (5)

4 (21)

 

 Anorexia

4 (21)

0 (0)

2 (11)

 

 Nausea/Vomiting

8 (42)

0 (0)

1 (5)

 

 Constipation

6 (32)

2 (11)

1 (5)

 

 Diarrhea

3 (16)

1 (5)

1 (5)

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