| Grade 1 | Grade 2 | Grade 3 | Grade 4 |
---|---|---|---|---|
Toxicity | No. (%) | No. (%) | No. (%) | No. (%) |
Injection-site reaction | 11 (53) | 1 (5) | 0 (0) | 0 (0) |
 Erythema | 9 (47) |  |  |  |
 Induration | 6 (32) | 1 (5) |  |  |
 Pain | 3 (16) |  |  |  |
 Ecchymosis | 2 (11) |  |  |  |
 Discoloration | 1 (5) |  |  |  |
 Edema | 1 (5) |  |  |  |
 Rash | 1 (5) |  |  |  |
 Reaction NOS | 1 (5) |  |  |  |
Toxicity unrelated to injection site | 10 (53) | 3 (16) | 4 (21) | 0 (0) |
 Pain | 10 (53) | 3 (16) | 2 (11) |  |
 Fatigue | 10 (53) | 1 (5) | 4 (21) |  |
 Anorexia | 4 (21) | 0 (0) | 2 (11) |  |
 Nausea/Vomiting | 8 (42) | 0 (0) | 1 (5) |  |
 Constipation | 6 (32) | 2 (11) | 1 (5) |  |
 Diarrhea | 3 (16) | 1 (5) | 1 (5) |  |