Skip to content

Advertisement

  • Oral presentation
  • Open Access

Cross-talks of tumor and myeloid cells regulate the therapeutic responses to chemotherapy by modulating innate immune responses

  • Masahisa Jinushi1,
  • Muhammad Baghdadi1 and
  • Hideo Yagita2
Journal for ImmunoTherapy of Cancer20131(Suppl 1):O16

https://doi.org/10.1186/2051-1426-1-S1-O16

Published: 7 November 2013

Keywords

Antitumor EffectMyeloid CellTherapeutic ResponseCytotoxic ChemotherapyRecognition Signal
Tumor-associated myeloid cells play a critical role in supporting tumor progression and metastasis. However, molecular mechanisms by which tumor cells interact with myeloid cells to modify therapeutic responses to anticancer treatments remain largely unknown. We identified several key factors affecting antitumor effects of chemotherapy by manipulating the modes of interaction between tumor cells and myeloid cells within tumor microenvironments. Tumor-derived factors such as VEGF-A and arginase-I upregulate TIM-3 on dendritic cells. TIM-3 interacts with HMGB1 released from chemotherapy-treated tumor cells, and suppresses innate pattern recognition signals mediated by nucleic acids from dying tumor cells. The inhibition of TIM-3 augments antitumor effects of cytotoxic chemotherapy against established tumors. Moreover, danger-associated molecular patterns (DAMPs) released from chemotherapy-damaged tumor cells induced TIM-4 on TAMs recruited from bone marrow-derived precursors. TIM-4 directly interacted with AMPK-α1 at phagosome and activated autophagy-mediated lysosomal degradation of ingested tumors, leading to reduced antigen presentation and impaired CTL responses. Consistently, blockade of the TIM-4/AMPK-α1/ autophagy pathway augmented antitumor effect of chemotherapeutics by enhancing tumor-specific CTL responses. Taken together, our findings provide new evidences that targeting of key factors regulating interplay between tumor cells and myeloid cells provides new therapeutic strategy to eradicate chemoresistant tumors.
Figure 1
Figure 1

Cross-talk between tumors and myeloid cells suppresses antitumor effect of chemotherapy.

Authors’ Affiliations

(1)
Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
(2)
Department of Immunology, Juntendo University, Tokyo, Japan

Copyright

© Jinushi et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Advertisement