Abstracts of the 28th Annual Scientific Meeting of the Society for Immunotherapy of Cancer (SITC)
- Poster presentation
- Open Access
HLA-G-specific microRNAs a novel approach for targeting tumors
Journal for ImmunoTherapy of Cancer volume 1, Article number: P174 (2013)
Immune inhibitory molecules on immune cells as well as on tumor cells appear to play a key role in modulating the immunogenicity of tumors and the efficacy of immunotherapies. One mediator is represented by the non-classical HLA-G antigen, which is often overexpressed in human tumors when compared to corresponding normal tissues thereby inhibiting both innate as well as adaptive immune responses. Since discordant HLA-G transcript and protein expression levels were often found in tumors of distinct origin posttranscriptional control mechanisms have been recently suggested. Indeed, different HLA-G-specific miRs have been identified, which were able to downregulate HLA-G surface expression. The miR-mediated inhibition of HLA-G enhanced the NK cell recognition. These miRs were also differentially expressed in renal cell carcinoma (RCC) versus normal kidney epithelium. Immunohistochemical analysis demonstrated of a high frequency HLA-G expression in RCC lesions, which was associated with disease progression and inversely correlated with the expression of HLA-G-specific miRs. These data postulate that HLA-G-specific miRs might be used as prognostic markers as well as potential therapeutics for targeting HLA-G expressing RCC.
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Jasinski-Bergner, S., Hartmann, A., Spath, V. et al. HLA-G-specific microRNAs a novel approach for targeting tumors. j. immunotherapy cancer 1 (Suppl 1), P174 (2013). https://doi.org/10.1186/2051-1426-1-S1-P174
- Renal Cell Carcinoma
- Prognostic Marker
- Surface Expression
- Adaptive Immune Response
- Protein Expression Level