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Volume 1 Supplement 1

Abstracts of the 28th Annual Scientific Meeting of the Society for Immunotherapy of Cancer (SITC)

Immunotherapy targeting esophageal cancer stem cells

Esophageal cancer is one of most common malignancies. Cancer stem cells (CSC) are considered to be resistant to chemotherapy and radiotherapy, which might be associated with the recurrence of the tumor after treatment. To find the therapeutic procedures targeting CSCs, the different methods have been used to identify the esophageal CSC-related genes and surface markers. The esophageal CSCs were found to resist the chemotherapy and the mechanism was explored as well. We also found the levels of tumor associated antigens in esophageal CSCs have differences comparing with the non-stem cancer cells. To understand if the tumor associated antigens can be used as targets by immune cells, we cloned the tumor antigen specific T cells and analyzed the T cell recognition of esophageal CSC both in vitro and in vivo. We found that the immunotherapy might be one of the optimal procedures targeting both non-stem cancer cells and esophageal CSC.

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Correspondence to Yi Zhang.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( https://creativecommons.org/publicdomain/zero/1.0/ ) applies to the data made available in this article, unless otherwise stated.

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Yue, D., Ren, H., Huang, L. et al. Immunotherapy targeting esophageal cancer stem cells. j. immunotherapy cancer 1, P178 (2013). https://doi.org/10.1186/2051-1426-1-S1-P178

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Keywords

  • Public Health
  • Cancer Cell
  • Stem Cell
  • Immune Cell
  • Esophageal Cancer