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Volume 1 Supplement 1

Abstracts of the 28th Annual Scientific Meeting of the Society for Immunotherapy of Cancer (SITC)

CD40 expression in renal cell carcinoma correlates with tumor apoptosis, CD8 T cell frequency and patient survival

Journal for ImmunoTherapy of Cancer volume 1, Article number: P65 (2013) Cite this article

Purpose

To investigate the relationship between tumor-associated CD40 expression, RCC patient survival and tumor stage.

Experimental design

The expression of CD40, TUNEL and CD8 in human renal cell carcinomas was analyzed by immunohistochemistry. Computer-assisted quantitation of protein expression was used to correlate results with patient survival and tumor stage.

Results

We show for the first time that tumor-associated CD40 expression correlates with prolonged survival in RCC patients. CD40 also correlated with TUNEL and CD8 staining in tumor tissues. No correlation was observed between CD40 and tumor stage.

Conclusions

Our results suggest CD40 may be a prognostic biomarker indicative of prolonged RCC patient survival. Strategies that up-regulate CD40 expression in some RCC patients might lead to improved survival. The further development and use of agonistic CD40 antibodies for treatment of RCC is warranted.

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Authors and Affiliations

  1. Cancer and Inflammation Program, NCI Frederick, CCR, Frederick, MD, USA

    Jonathan M Weiss, Jimmy K Stauffer & Robert H Wiltrout

  2. Statistical Consulting, DMS, Frederick National Laboratory for Cancer Research, Frederick, MD, USA

    Gregory Alvord & Octavio A Quinones

Authors
  1. Jonathan M Weiss
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  2. Gregory Alvord
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  3. Octavio A Quinones
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  4. Jimmy K Stauffer
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  5. Robert H Wiltrout
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Weiss, J.M., Alvord, G., Quinones, O.A. et al. CD40 expression in renal cell carcinoma correlates with tumor apoptosis, CD8 T cell frequency and patient survival. j. immunotherapy cancer 1 (Suppl 1), P65 (2013). https://doi.org/10.1186/2051-1426-1-S1-P65

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  • DOI: https://doi.org/10.1186/2051-1426-1-S1-P65

Keywords

  • Carcinoma
  • Protein Expression
  • Tumor Tissue
  • Renal Cell Carcinoma
  • Patient Survival