Figure 2

Genes differentially expressed in patients’ tumor microenvironment before and after rV-B7.1 treatment. Gene expression profiles from metastatic melanoma lesions were obtained from fine needle aspiration (FNA) samples (n = 5) before (pre) the first and four weeks after (post) the third intra-tumoral rV-B7.1 vaccination and analyzed using a customized 32x24x23 (~17,000 spot) human cDNA microarray. (A) The resultant heat map is shown. (B) Fold change (post / pre) of ILT2 gene expression in tumor FNAs from (A) shown for responders (n = 2) and non-responders (n = 3). PD = progressive disease, SD = stable disease, PR = partial response.