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Table 1 IL-2 responsiveness in peripheral blood T cells before and after DC vaccination

From: Cytokine responsiveness of CD8+ T cells is a reproducible biomarker for the clinical efficacy of dendritic cell vaccination in glioblastoma patients

Patient ID

Overall survival (months)

Pre-DC Vax CD3+CD8+ EC-50

Post-DC Vax CD3+CD8+ EC-50

Pre-DC Vax CD3+CD4+ EC50

Post-DC Vax CD3+CD4+ EC-50

1-708

33.83

128.2

13.16

3.528

13.39

34-730

16.23

126.2

66.01

20.73

0.005

36-852

>43.9

27.95

0.017

4.407

0.002

6-815

17.3

1.854

0.196

0.002

2.355

19-539

34.9

8.223

14.27

1.386

1.178

GAA-03

35.3

60.52

18.63

29.64

0.003

GAA-05

11.73

38.2

34.69

11.43

5.245

GAA-07

17.2

16.52

6.07

5.446

5.237

GAA-09

11.0

31.19

22.38

7.2

7.7

AVERAGE:

 

50.70

19.15

9.31

3.90

SEM:

 

16.90

6.38

3.10

1.30

T-test:

 

0.045

 

0.223

 
  1. 1The EC-50 for IL-2 responsiveness (pSTAT-5) was calculated in CD3+8+ and CD3+CD4+ peripheral blood T cells after a 20-minute stimulation with increasing dosages of IL-2, FACS analysis, and log transformation.