Figure 3

The percent changes of measurements using irRC simulating RECIST1.0 and irRC simulating RECIST1.1 at each follow-up from the 1 ^st to the 17 ^th follow-up scans are shown. Dashed lines at +20% and -30% represent the cut-off values for progressive disease and partial response, respectively. The observations within the lower left, middle center, and upper right boxes have concordant assessment between tow measurements, while observations in other boxes have discordant assessment. One concordant observation (+80% by irRC simulating RECIST1.0, +330% irRC simulating RECIST1.1) is not displayed since it is beyond the range of the Y axis.). The percent changes presented in the figure are in comparison with baseline measurements when tumors are decreasing to assess response, and in comparison with the nadir (the smallest measurement since baseline) when tumors are increasing to assess progression. These values are displayed since they are used to define response/progression in patients at the time of response assessment. Please also note that the number of patients decreases as the follow-up proceeds, starting from 71 patients at 1^st follow-up, 43 patients at the 2^nd follow-up, 27 patients at the 3^rd follow-up, and so on. There were 3 patients at the 12^th -14^th follow-up, 2 patients at 15^th and 16^th follow-up, and one follow-up at the 17^th follow-up.