Figure 2

Maximum tumor reduction (per Independent radiologic review) in study patients receiving IL-21 (10-50 mcg/kg) plus sorafenib (starting at 400 mg twice daily). The maximum percent change from baseline in the sum of the longest diameters of target lesions per RECIST v1.0 is depicted for the study patients. (NOTE: Two patients from phase 2 are not included due to clinical progressive disease in one patient and withdrawal from the study due to an AE prior to the restaging evaluation in another patient).