Cytokine secretion in response to 6MHP stimulation. PBMC (week 5, left panels) and SIN lymphocytes (day 22, right panels) were stimulated with 6MHP after CFSE labeling, then tested for IL-5 (top panels) production or IFN-γ (bottom panels) production. Data are shown for cells from a representative patient (patient 8) gated on lymphocytes, CD3-positive, and CD8-negative. The cells secreting cytokine are represented in the left upper quadrant of each plot, with percentages shown for each quadrant. IFN-γ producing cells are 8-9 fold more prevalent than IL-5 secreting cells in both PBMC and SIN’s.