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Table 1 Summary of 2-day response data

From: A melanoma helper peptide vaccine increases Th1 cytokine production by leukocytes in peripheral blood and immunized lymph nodes

  PBMC (n = 23) SIN(n = 22)
Cytokine Mean pre-vaccine(pg/ml) Mean post-vaccine(pg/ml) Number with increase(p value) Mean at day 22
IFN-γ 8.7 121 15 (p = 0.04) 51.2
IL-2 0.8 13.7 15 (p = 0.07) 62.3
TNF-α 15.2 16.1 10 (p = ns) 4.4
IL-4 0.8* 5.0* 7 (p = ns) 2.8
IL-5 0.2 20.7 14 (p = ns) 12.7
IL-10 1.1* 1.6* 9 (p = ns) 2.1
Th1 sum 24.8 150.9 17 (p = 0.036) 118
Th2 sum 2.1 27.3 14 (p = 0.042) 17.6
IFN vs IL-5 0.2 vs 8.7 20.7 vs 121 p = 0.005 p = 0.010
Th1 NED 12.1 174 p = 0.091 162
Th1 Disease 41.2 111 66
Total cytokines NED 14.3 211 p = 0.11 188
Total cytokines Disease 43.1 120   65
  1. Means of cytokines and assessments of individual cytokine responses to vaccination with 6MHP. Increase from baseline required values within linear range of cytokine assay. Mean values reflect aggregate activity and outliers are notable as seen in the figures. All values are corrected for background PBMC is peripheral blood mononuclear cells and SIN are sentinel immunized nodes. NED = no evidence of disease.
  2. *Some samples zeroed based on background correction.