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Table 1 Summary of 2-day response data

From: A melanoma helper peptide vaccine increases Th1 cytokine production by leukocytes in peripheral blood and immunized lymph nodes

 

PBMC (n = 23)

SIN(n = 22)

Cytokine

Mean pre-vaccine(pg/ml)

Mean post-vaccine(pg/ml)

Number with increase(p value)

Mean at day 22

IFN-γ

8.7

121

15 (p = 0.04)

51.2

IL-2

0.8

13.7

15 (p = 0.07)

62.3

TNF-α

15.2

16.1

10 (p = ns)

4.4

IL-4

0.8*

5.0*

7 (p = ns)

2.8

IL-5

0.2

20.7

14 (p = ns)

12.7

IL-10

1.1*

1.6*

9 (p = ns)

2.1

Th1 sum

24.8

150.9

17 (p = 0.036)

118

Th2 sum

2.1

27.3

14 (p = 0.042)

17.6

IFN vs IL-5

0.2 vs 8.7

20.7 vs 121

p = 0.005

p = 0.010

Th1 NED

12.1

174

p = 0.091

162

Th1 Disease

41.2

111

66

Total cytokines NED

14.3

211

p = 0.11

188

Total cytokines Disease

43.1

120

 

65

  1. Means of cytokines and assessments of individual cytokine responses to vaccination with 6MHP. Increase from baseline required values within linear range of cytokine assay. Mean values reflect aggregate activity and outliers are notable as seen in the figures. All values are corrected for background PBMC is peripheral blood mononuclear cells and SIN are sentinel immunized nodes. NED = no evidence of disease.
  2. *Some samples zeroed based on background correction.
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