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Figure 5 | Journal for ImmunoTherapy of Cancer

Figure 5

From: Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells

Figure 5

PBL transduced with murine CARs targeting CSPG4 recognize tumor lines from multiple cancer histologies. All CARs shown use the second generation CD28.CD3ζ signaling domain. A1207 = glioblastoma multiforme cell line, Mill = mesothelioma, MDAMB231 = breast cancer cell lines, MgG-63 = osteosarcoma cell line, mel938 = melanoma cell lines, H1299A = non-small cell lung cancer line (negative control). Anti-CSPG4 CAR-transduced T cells activity was statistically significant (p < 0.05, student’s t-test) in all comparisons to GFP control transduced T cells versus H1299 cells from donor 4. Anti-CSPG4 CAR-transduced T cells activity was statistically significant (p < 0.05) in all comparisons of TP41.2 and 149.53 CAR transduced cells to GFP control transduced T cells versus H1299 cells from donor 5. There was no significant difference in activity of 225.28S CAR transduced cells to GFP control transduced T cells versus H1299 cells from donor 5 in cocultures with MgG-63 and mel938 cells (p > 0.05).

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