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Figure 6 | Journal for ImmunoTherapy of Cancer

Figure 6

From: Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells

Figure 6

CAR transduced T cell produce multiple effector cytokines. TP41.2 anti-CSPG4 CAR transduced T cells from two different donors (donors 6 and 7) were cocultured with melanoma (mel1300) and glioblastoma (LN443) tumor cell lines to determine effector cytokine release (H1299 was used as a CSPG4 negative control line). IFN-γ, TNF-α, and GMCSF production was determined by ELISA (mean of triplicate determinations). Anti-CSPG4 CAR-transduced T cells activity (stripped bars) was statistically significant (p < 0.05, student’s t-test) in all comparisons to GFP control (black bars) transduced T cells.

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