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Figure 7 | Journal for ImmunoTherapy of Cancer

Figure 7

From: Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+ T cells directly within the tumor microenvironment

Figure 7

Immunotherapy doublets result in increased frequencies of tumor antigen-specific T cells at later time points in the periphery. Depicted is an IFN-γ ELISpot of splenocytes harvested on day 14 with open bars being the un-stimulated control and filled bars representing SIY-stimulation. Data are shown as the mean +/− SEM from 10 mice pooled from two experiments. Statistical analysis was done using Mann–Whitney-U test comparing all groups to no treatment. All double treatment groups were significantly different to their respective single treatment and when comparing double treatments within each other a significant difference between αCTLA4 + αPD-L1 and αPD-L1 + IDOi was observed.

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