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Figure 1 | Journal for ImmunoTherapy of Cancer

Figure 1

From: Stem cells and cancer immunotherapy: Arrowhead’s 2nd annual cancer immunotherapy conference

Figure 1

Target characteristics and corresponding therapeutic approaches. This diagram outlines the major desirable characteristics of new targets for immune interventions. Depending on expression pattern, such targets fall into two categories: 1) with membrane expression and thus targetable by antibodies, antibody drug conjugates, bispecific antibodies/constructs, CAR-engineered T cells and certain vaccines that induce antibodies; and 2) expressed inside the cells, and thus amenable to vaccines, tumor infiltrating lymphocytes, small molecules, re-programmed T cells and NKT cells.

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