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Table 1 TNFR-targeted agents in development

From: Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy

TNF receptor molecule Name Description Sponsor Phase in cancer patients
4-1BB (CD137) CART19 cells T cells transduced with antibody against CD19 linked to the intracellular signaling domains of 4-1BB and CD3-zeta University of Pennsylvania and others II
Urelumab Fully human anti-CD137 agonist monoclonal antibody Bristol Myers-Squibb I
OX40   Mouse monoclonal anti-OX40 agonist antibody Providence Health & Services and others II
  Humanized antibody against OX40   Preclinical
hFcILZOX40L Recombinant human Fc:OX40L fusion protein Providence Portland Medical Center Preclinical
GITR TRX518 Humanized anti-GITR agonist monoclonal antibody GITR, Inc. I
GITRL RNA DC GITRL-expressing DCs Duke University I
CD27 CDX-1127 Fully human anti-CD27 agonist monoclonal antibody Celldex Therapeutics I
  1. Abbreviation: DCs Dendritic Cells, GITR Glucocorticoid-Induced TNFR-Related Gene, GITRL GITR Ligand, TNF Tumor-Necrosis Factor, TNFR Tumor-Necrosis Factor Receptor.