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Volume 2 Supplement 3

Abstracts of the 29th Annual Scientific Meeting of the Society for Immunotherapy of Cancer (SITC)

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Gefitinib in treatment of metastatic non-small cell lung cancer (NSCLC) with mutated epidermal growth factor receptor (EGFR)


To evaluate the efficacy, toxicity, overall survival and response of Gefitinib in previously untreated patients of metastatic NSCLC with EGFR mutation.


60 patients with metastatic, non-small-cell lung cancer and EGFR mutations who had not previously received chemotherapy were randomly assigned to receive Gefitinib 250 mg orally daily or carboplatin -paclitaxel. The primary end point was progression-free survival; secondary end points included overall survival, response rate, and toxic effects.


The progression free survival was significanly longer in Gefitinb group than in standard chemotherapy group. The Gefitinib group had significantly longer median progression free survival (10 months versus 5 months) as well as higher response rates (70% versus 30%). The median overall survival was 30 months in Gefitinib group and 24 months in chemotherapy group. The most common adverse events in Gefitinib group were rash and elevated aminotransferase levels.


First-line Gefitinib for patients with advanced non-small-cell lung cancer who were selected on the basis of EGFR mutations improved progression-free survival, with acceptable toxicity, as compared with standard chemotherapy.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Singh, C. Gefitinib in treatment of metastatic non-small cell lung cancer (NSCLC) with mutated epidermal growth factor receptor (EGFR). j. immunotherapy cancer 2 (Suppl 3), P187 (2014).

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