Abstracts of the Breast Cancer Immunotherapy Symposium (BRECIS): Sidra Symposia Series
- Poster presentation
- Open Access
- Published:
Haplotypes of SNPs associated with COX-2 and their comparison with histopathological features of breast cancer patients
Journal for ImmunoTherapy of Cancer volume 3, Article number: P9 (2015)
Introduction
In breast cancer, increased cyclooxygenase-2 expressions is associated with poor prognosis. COX-2 expression influences production of pro-inflammatory prostaglandins. The present study investigated association between COX-2 promoter polymorphisms (rs689465, rs689466, rs20417) and histopathological features of breast cancer patients.
Methods
We selected 150 HER-2 amplification positive breast cancer patients from our previous case-control study. The participants were evaluated for histopathological features and genotyped for COX-2 SNPs. Comparisons of genotype data with histopathological characteristics were performed by chi square test. Logistic regression was applied for estimation of odd ratios. COX-2 protein level and other markers were assessed by immunohistochemical staining. Statistical analyses were performed using SPSS version 19.0 and p value was set at <0.05.
Results
Our data showed that elevated COX-2 expression was significantly associated with HER-2 amplified tumours. In addition, a positive association between rs20417 (GC+CC) and estrogens receptor (OR: 0.383, 0.161-0.913, P: 0.030) and IDC tumour (OR: 0.264, 0.070-0.993, P: 0.049) was noted. Eight haplotypes were deduced and associations with tumour size (P: 0.030), HER-2 amplification (P: < 0.0001), ER positivity (P: 0.017) were observed.
Conclusion
Present study suggests that COX-2 expression and haplotypes of its associated SNPs should be considered for characterizing breast cancer prognosis.
Author information
Authors and Affiliations
Rights and permissions
Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.
The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Aban, M., Siddqui, I., Saboor, M. et al. Haplotypes of SNPs associated with COX-2 and their comparison with histopathological features of breast cancer patients. j. immunotherapy cancer 3 (Suppl 1), P9 (2015). https://doi.org/10.1186/2051-1426-3-S1-P9
Published:
DOI: https://doi.org/10.1186/2051-1426-3-S1-P9
Keywords
- Breast Cancer
- Breast Cancer Patient
- Promoter Polymorphism
- Positive Breast Cancer
- Cancer Prognosis