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Volume 3 Supplement 2

30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015)

Immune profiling in human breast cancer is predictive of 5- and 10-year survival.

Journal for ImmunoTherapy of Cancer volume 3, Article number: P131 (2015) Cite this article

Background

Immunotherapy for breast cancer is now being seriously considered, despite past beliefs that this cancer type was non-immunogenic. Immune profiling has been variably associated with outcome, but standard techniques have greatly limited interpretation. These studies examine immune profiling of breast cancer patients using high-sensitivity methods in relation to clinical outcome.

Methods

High-sensitivity detection and analysis methods were used to determine Immune Profiles of female human breast cancer in Tumour Infiltrating Leukocytes (TIL) in longitudinal cohort comparative outcome studies.

Results

Immune profiles showed predominantly CD3, CD4, CD45RO TIL with low/absent IL-2a receptor expression. However, these were significantly correlated to 5- and 10-year survival times.

Conclusions

Immune profiling of the TIL infiltrate in human breast carcinoma using high-sensitivity detection and analysis techniques showed predominance of CD3 cells, being ab-TCR, CD4 T cells of mainly memory phenotype. Importantly, these findings were strongly predictive of 5- and 10-year survival. This indicates the real possibility that TIL infiltration in breast cancer might be open to immunological manipulation therapeutically to improve clinical outcome.

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Authors and Affiliations

  1. Discipline of Surgery, University of Adelaide & Breast, Endocrine & Surgical Oncology Unit, Royal Adelaide Hospital, Australia

    Brendon Coventry & Michael J Weightman

  2. Department of Clinical Immunology, Flinders University, Flinders Medical Centre, Adelaide, Australia

    John Bradley

  3. Pathology, Flinders University, Flinders Medical Centre, Adelaide, Australia

    John M Skinner

Authors
  1. Brendon Coventry
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  2. Michael J Weightman
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  3. John Bradley
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  4. John M Skinner
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Coventry, B., Weightman, M.J., Bradley, J. et al. Immune profiling in human breast cancer is predictive of 5- and 10-year survival.. j. immunotherapy cancer 3 (Suppl 2), P131 (2015). https://doi.org/10.1186/2051-1426-3-S2-P131

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  • DOI: https://doi.org/10.1186/2051-1426-3-S2-P131

Keywords

  • Breast Cancer
  • Breast Cancer Patient
  • Breast Carcinoma
  • Human Breast Cancer
  • Receptor Expression