30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015)
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Tumor and host characteristics of small cell lung cancer (SCLC) in U.S. community oncology practice
Journal for ImmunoTherapy of Cancer volume 3, Article number: P170 (2015)
Background
The majority of lung cancer in the U.S. is treated in the community. A prospective cohort study of stage IV NSCLC and extensive disease (ED) SCLC is being conducted in 70 U.S. community practices to assess outcomes during the pre- and post-immunotherapy eras of lung cancer treatment. This analysis focuses on characteristics of the rarer SCLC subset in the pre-immunotherapy era.
Methods
ED SCLC patients, at any point in their care, with documented dates of diagnosis and prior treatment are eligible. Patients are followed prospectively for 36 months or until death, with data abstraction from medical records. Archival tumor tissue (formalin-fixed paraffin-embedded) slides are used to measure PD-L1 protein expression with a validated, automated immunohistochemistry (IHC) assay from Dako using the 28-8 antibody. Expression levels of tumor cell membrane staining at any intensity were defined for ≥1% and ≥ 5% of 100 assessable tumor cells.
Results
Data from 268 cases with complete records are reported. At enrollment, 95% were ever smokers, 53% female, and 26% ECOG performance status (PS) 2 or 3. The most prevalent sites of metastases were liver (34%), bone (32%), and brain (21%). History of a specific autoimmune condition was present in 8% of cases. The median overall survival from diagnosis with extensive disease will be reported. PD-L1 IHC was performed on 96/268 patients with available tissue and was evaluable in 87/96 cases. PD-L1 was expressed at ≥1% for 13 cases (15%) and ≥5% for 2 (2%) cases. Of these, 85 had hematoxylin and eosin (H&E) staining performed showing tumor inflammation in 62% and tumor necrosis in 41% of cases. An intra-tumoral inflammatory infiltrate of ≥10% was observed in 49% of cases and is associated with PD-L1 expression at ≥1% (P < 0.003).
Conclusion
Many immunotherapy clinical trials exclude patients with active or untreated brain metastases and patients receiving treatment for autoimmune disease, yet a substantial proportion of community-based SCLC patients present with these attributes. PD-L1 expression levels in SCLC appear lower than those previously reported in NSCLC. The role of PD-L1 and other tumor and blood-based markers as prognostic or predictive for SCLC outcomes will be investigated in this ongoing study.
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Richards, D., Li, S.G., Anderson, T. et al. Tumor and host characteristics of small cell lung cancer (SCLC) in U.S. community oncology practice. j. immunotherapy cancer 3 (Suppl 2), P170 (2015). https://doi.org/10.1186/2051-1426-3-S2-P170
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DOI: https://doi.org/10.1186/2051-1426-3-S2-P170
Keywords
- Small Cell Lung Cancer
- Extensive Disease
- Small Cell Lung Cancer Patient
- Lung Cancer Treatment
- Tumor Cell Membrane