Skip to main content

Advertisement

Cyclic dinucleotides (CDNs) reversed T cells tolerance in anti-tumor immunotherapy

  • 506 Accesses

One important barrier to cancer immunotherapy. We used cyclic dinucleotides (CDNs) and Listeria vaccine and LPS treated HA-specific CD8 tolerance B10. D2 mice. Our results demonstrated T cells IFN-gamma increased in CDNs and Listeria vaccine plus CDNs treatment groups. But CDNs didn't significantly increase Treg cells. The data showed CDNs can reverse established T cell tolerance that improved cancer immunotherapy in the future. We will further explore T cells tolerance in cancer bearing T cell tolerance mice model in vivo.

Author information

Correspondence to Young Kim.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Fu, J., Kim, Y., Kanne, D. et al. Cyclic dinucleotides (CDNs) reversed T cells tolerance in anti-tumor immunotherapy. j. immunotherapy cancer 3, P268 (2015) doi:10.1186/2051-1426-3-S2-P268

Download citation

Keywords

  • Public Health
  • Treatment Group
  • Mouse Model
  • Dinucleotide
  • Treg Cell