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Volume 3 Supplement 2

30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015)

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Cyclic dinucleotides (CDNs) reversed T cells tolerance in anti-tumor immunotherapy

Journal for ImmunoTherapy of Cancer volume 3, Article number: P268 (2015) Cite this article

One important barrier to cancer immunotherapy. We used cyclic dinucleotides (CDNs) and Listeria vaccine and LPS treated HA-specific CD8 tolerance B10. D2 mice. Our results demonstrated T cells IFN-gamma increased in CDNs and Listeria vaccine plus CDNs treatment groups. But CDNs didn't significantly increase Treg cells. The data showed CDNs can reverse established T cell tolerance that improved cancer immunotherapy in the future. We will further explore T cells tolerance in cancer bearing T cell tolerance mice model in vivo.

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Authors and Affiliations

  1. Johns Hopkis Unversity, Baltimore, MD, USA

    Juan Fu

  2. Johns Hopkins University, Baltimore, MD, USA

    Young Kim, Qi Zeng, Drew Pardoll & Shekhar Gadkare

  3. Aduro BioTech, Berkeley, CA, USA

    David Kanne

  4. Aduro BioTech, Berkely, CA, USA

    Meredith Leong & Thomas Dubensky

  5. Johns Hopkins Unversity, Baltimore, MD, USA

    Rupashree Sen

  6. Johns Hopins University, Baltimore, MD, USA

    Todd D Amstrong

  7. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA

    Charles G Drake

Authors
  1. Juan Fu
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  2. Young Kim
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  3. David Kanne
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  4. Meredith Leong
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  5. Qi Zeng
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  6. Rupashree Sen
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  7. Todd D Amstrong
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  8. Charles G Drake
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  9. Thomas Dubensky
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  10. Drew Pardoll
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  11. Shekhar Gadkare
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Fu, J., Kim, Y., Kanne, D. et al. Cyclic dinucleotides (CDNs) reversed T cells tolerance in anti-tumor immunotherapy. j. immunotherapy cancer 3 (Suppl 2), P268 (2015). https://doi.org/10.1186/2051-1426-3-S2-P268

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  • DOI: https://doi.org/10.1186/2051-1426-3-S2-P268

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