30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015)
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Sub-lethal ionizing radiation alters Foxp3 expression in CD4+ T regulatory (Treg) cells in vitro and in vivo
Journal for ImmunoTherapy of Cancer volume 3, Article number: P269 (2015)
The use of sub-lethal radiation has been shown to alter cell phenotype and gene expression. T regulatory (Treg) cells are phenotypically defined as being CD4+CD25+ Foxp3+ T cells and are known to suppress the function of CD8+ cytotoxic T lymphocytes (CTLs). Inhibiting the suppressive function of Treg cells allows for activation and proliferation of CD8+ CTLs. We examined the effects of sub-lethal radiation on Tregs 24- to 72-hrs post-treatment. We found that radiation treatment decreased the number of Treg cells however the total CD4+ T cell fraction remained unaltered. Our data suggests that the use of sub-lethal radiation can modulate the expression of Foxp3 in CD4+ Treg cells in vitro and in vivo. Moreover, the loss of Foxp3-mediated suppressive functions may be linked to increased CTL activity.
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Kumari, A., Simon, S. & Garnett-Benson, C. Sub-lethal ionizing radiation alters Foxp3 expression in CD4+ T regulatory (Treg) cells in vitro and in vivo. j. immunotherapy cancer 3 (Suppl 2), P269 (2015). https://doi.org/10.1186/2051-1426-3-S2-P269
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DOI: https://doi.org/10.1186/2051-1426-3-S2-P269
Keywords
- Public Health
- Gene Expression
- Treg Cell
- Radiation Treatment
- Cell Phenotype