From: Relationship between immune gene signatures and clinical response to PD-1 blockade with pembrolizumab (MK-3475) in patients with advanced solid tumors
Signature
HNSCC
Gastric Cancer
ORR
PFS
IFN-λ
0.005
<0.001
0.077
0.032
TCR signaling
0.071
0.002
0.034
0.024
Expanded immune
0.015
0.062
0.049
De novo
0.018
0.068
0.037