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Volume 3 Supplement 2

30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015)

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Prognostic and biologic significance of high LCK expression in ovarian cancer

Journal for ImmunoTherapy of Cancer volume 3, Article number: P93 (2015) Cite this article

Introduction

Epithelial ovarian cancer is the most lethal and second most common gynecologic cancer in the United States. Previous studies have demonstrated the favorable prognostic value of tumor infiltrating lymphocytes in this disease. The objective of this study was to evaluate the prognostic value and the biological correlates for lymphocyte specific kinase (LCK) expression in high grade serous ovarian cancer.

Methods

LCK mRNA and protein (included in the reverse Phase protein array (RPPA) data) expression was evaluated using the ovarian cancer TCGA dataset. Gene expression was compared between the LCK high and normal tumors was compared. LCK protein expression was also evaluated using IHC in an independent set of high grade serous ovarian cancers, borderline tumors, benign cystadenomas, and normal fallopian tubes (tissue of origin of serous neoplasms).

Results

Using a SD of 1.86 above the mean as a cutoff, LCK mRNA high samples were associated with both an improved progression free and overall survival (p

Conclusions

LCK serves as a biomarker of prognostic and biological importance in ovarian cancer. Ongoing investigation is aimed at better understanding the immunological correlates of high LCK expression in ovarian cancer.

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Authors and Affiliations

  1. UT MD Anderson Cancer Center, Houston, TX, USA

    Amir Jazaeri, Qian Zhang, Melinda Yates, Caitlin Creasy, Chantale Bernatchez & Patrick Hwu

  2. Women and Infants Hospital/The Warren Alpert School of Medicine of Brown University, Providence, RI, USA

    Cherie Paquette

  3. University of Virginia, Charlottesville, VA, USA

    Sarah M Kelting & Mark H Stoler

Authors
  1. Amir Jazaeri
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  2. Cherie Paquette
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  3. Sarah M Kelting
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  4. Mark H Stoler
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  5. Qian Zhang
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  6. Melinda Yates
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  7. Caitlin Creasy
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  8. Chantale Bernatchez
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  9. Patrick Hwu
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Jazaeri, A., Paquette, C., Kelting, S.M. et al. Prognostic and biologic significance of high LCK expression in ovarian cancer. j. immunotherapy cancer 3 (Suppl 2), P93 (2015). https://doi.org/10.1186/2051-1426-3-S2-P93

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  • DOI: https://doi.org/10.1186/2051-1426-3-S2-P93

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