Figure 2

Timing of the administration of the 6th and 7th IV boluses of IL-2 is plotted versus systolic and diastolic blood pressure and heart rate. This patient is unresponsive to a fluid bolus and phenylephrine is begun at 50 mcg per minute with good effects permitting administration of the 7th dose. The resulting hypotension and tachycardia are treated with an increase in the phenylephrine dose and another bolus of fluid. The late night dose will likely be held.