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Table 2 Relative affinity of binding between the major Fc γRs and IgG Isotypes in human and mouse

From: The role of Fc gamma receptors in the activity of immunomodulatory antibodies for cancer

Human Mouse
FcγR IgG1 IgG2 IgG4 FcγR IgG1 IgG2a IgG2b
I ++++ - ++++ I - ++++ ++++
IIa H131 +++ ++ ++ III ++ ++ ++
R131 +++ + ++
IIb ++ - ++ IIB +++ ++ +++
IIIa V158 +++ + ++ IV - +++ ++
F158 ++ - ++
  1. Italics indicates an inhibitory receptor. Normal text indicates an activating receptor. Rankings are based on KA x105M−1 for each interaction reported in published studies [1],[5],[6]. ++++ indicates a KA greater than 100 x 105 M−1, +++ indicates a KA between 20 and 99 x 105 M−1, ++ indicates a KA between 1 and 19 × 105 M−1, + indicates a KA between 0.5 and 0.9 × 105 M−1, − indicates a KA that was undetectable or less than 0.5 × 105 M−1 .