The role of Fc gamma receptors in the activity of immunomodulatory antibodies for cancer

Table 2 Relative affinity of binding between the major Fc γRs and IgG Isotypes in human and mouse

Italics indicates an inhibitory receptor. Normal text indicates an activating receptor. Rankings are based on K_A x10⁵M⁻¹ for each interaction reported in published studies [1],[5],[6]. ++++ indicates a K_A greater than 100 x 10⁵ M⁻¹, +++ indicates a K_A between 20 and 99 x 10⁵ M⁻¹, ++ indicates a K_A between 1 and 19 × 10⁵ M⁻¹, + indicates a K_A between 0.5 and 0.9 × 10⁵ M⁻¹, − indicates a K_A that was undetectable or less than 0.5 × 10⁵ M⁻¹ .