|
ID
|
No. DC injection
|
DTH
|
CD4 T cell response
|
CD8 T cell response
|
MDSCs*
|
Tregs*
|
IL-8†
|
Change in Target Lesions (%)
|
Clinical Response‡
|
PFS§(d)
|
OS§(d)
|
Prognosis
|
|---|
|
1802
|
6
|
+
|
+
|
+
|
decreased
|
decreased
|
low
|
−25.4
|
SD
|
173
|
339
|
Dead
|
|
1803
|
6
|
-
|
+
|
-
|
decreased
|
decreased
|
low
|
0
|
SD
|
200
|
353
|
Dead
|
|
1806
|
6
|
-
|
-
|
-
|
decreased
|
no change
|
high
|
−18.4
|
N.A.¶
|
100
|
100
|
Dead
|
|
1808
|
6
|
-
|
-
|
-
|
no change
|
increased
|
high
|
−5.4
|
SD
|
155
|
193
|
Dead
|
|
1812
|
6
|
-
|
-
|
+
|
no change
|
no change
|
low
|
30.3
|
PD#
|
101
|
1140||
|
Alive
|
|
1814
|
12
|
+
|
+
|
+
|
decreased
|
decreased
|
low
|
−100
|
CR
|
347
|
1127||
|
Alive
|
|
1817
|
6
|
-
|
-
|
-
|
no change
|
increased
|
high
|
−27.8
|
PD**
|
88
|
206
|
Dead
|
|
1823
|
12
|
+
|
+
|
+
|
decreased
|
no change
|
high
|
−35.3
|
PR
|
342||
|
342||
|
Alive
|
- PFS, progression free survival; OS, overall survival; CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease.
- *Compared to the baseline.
-
†High or low is defined as more or less than 60 pg/ml in sera.
-
‡4wks after last injection.
-
§From the registration (days).
-
¶Withdrawn from the study by sudden hypertensive cerebral hemorrhage.
-
||A censored case due to the termination of the study.
-
#After surgical removal of target lesion (LN metastasis), no recurrence was observed.
-
**Though target lesion became smaller, accumulation of pleural effusion was increased.
