| Grade | |||||
---|---|---|---|---|---|---|
Adverse Events, Regardless of Causality | All | 1 | 2 | 3 | 4 | 5 |
General disorders | ||||||
Fatigue | 2 | Â | 2 | Â | Â | Â |
Pyrexia | 2 | 1 | 1 | Â | Â | Â |
Insomnia | 1 | Â | 1 | Â | Â | Â |
Gastrointestinal disorders | ||||||
Dyspepsia | 2 | Â | 2 | Â | Â | Â |
Dysgeusia | 2 | 1 | 1 | Â | Â | Â |
Diarrhea | 2 | 2 | Â | Â | Â | Â |
Nausea | 1 | 1 | Â | Â | Â | Â |
Esophagitis | 1 | 1 | Â | Â | Â | Â |
Respiratory, thoracic and mediastinal disorders | ||||||
Cough | 1 | Â | 1 | Â | Â | Â |
Musculoskeletal and connective tissue disorders | ||||||
Back pain | 3 | 1 | 2 | Â | Â | Â |
Metabolism and nutrition disorders | ||||||
Hypothyroidism | 4 | Â | 4 | Â | Â | Â |
Skin and subcutaneous tissue disorders | ||||||
Hand-foot syndrome | 8 | 2 | 6 | Â | Â | Â |
Stomatitis | 4 | 2 | 2 | Â | Â | Â |
Peripheral Edema | 4 | 3 | 1 | Â | Â | Â |
Anal diseases | 3 | Â | 3 | Â | Â | Â |
Skin ulceration | 1 | Â | 1 | Â | Â | Â |
Pruritus | 1 | Â | 1 | Â | Â | Â |
Trichophytosis | 1 | Â | 1 | Â | Â | Â |
Rash | 1 | 1 | Â | Â | Â | Â |
Vascular disorders | ||||||
Hypertension | 3 | Â | 1 | 1 | Â | 1* |
Hematological and other laboratory abnormalities | ||||||
Anemia | 3 | Â | 1 | 2 | Â | Â |
Leukopenia | 3 | Â | Â | 3 | Â | Â |
Neutropenia | 3 | Â | Â | 3 | Â | Â |
Lymphocytopenia | 3 | Â | Â | 3 | Â | Â |
Thrombocytopenia | 3 | Â | Â | 3 | Â | Â |
Increased creatinine | 2 | Â | Â | 2 | Â | Â |