Immune parameter | Mean treatment-induced increase (range)* | Cut-off†| Median survival between groups‡ (# of patients in each group) | p-value§ | Hazard ratio (95% CI HR) | Mean Halabi Predicted Survival¶ | p-value׀׀ |
---|---|---|---|---|---|---|---|
CD40 on cDC1 | 313% (-67 to +1194) | 70% | 38.5 vs. 15.5(22 vs. 6) | 0.0004 | 0.052 (0.010-0.267) | 18.7 vs. 16.6 | 0.614 |
CD40 on cDC2 | 170% (-52 to +612) | 150% | 36.5 vs. 25.5 (10 vs. 18) | 0.397 | 0.688 (0.299-1.582) | 16.8 vs. 19.1 | 0.338 |
CD40 on cDC3 | 160% (-16 to +765) | 70% | 40.0 vs. 19.0 (19 vs. 9) | 0.0031 | 0.179 (0.057-0.560) | 18.6 vs. 17.7 | 0.684 |
CD40 on pDC | 290% (-19 to +1814) | 450% | 26.0 vs. 31.5 (4 vs. 26) | 0.739 | 1.226 (0.373-4.032) | 14.2 vs. 19.0 | 0.168 |
CD40 on monocytes | 243% (-28 to +1001) | 160% | 57.0 vs. 21.0 (9 vs. 19) | 0.0749 | 0.469 (0.204-1.079) | 20.1 vs. 17.4 | 0.192 |
Lin-CD14+HLA-DR?mMDSC | 87% (-71 to +543) | 60% | 35.0 vs. 36.0 (8 vs. 11) | 0.270 | 0.559 (0.198-1.572) | 16.7 vs. 21.4 | 0.139 |