Clinical exam photographs, imaging (PET/CT), tumor marker (CA 27-29) and treatment regimens according to timeline for patient 2. At initial presentation of the patient in August 2009, the locally advanced breast cancer involved the overlying skin, axillary lymph nodes and invaded the pectoralis muscle. In addition an adrenal metastasis and mediastinal lymph nodes were detected by imaging. Interval treatments included paclitaxel, trastuzumab, LH-RH agonist, tamoxifen, topical imiquimod followed by fulvestrant, on which the patient experienced a complete response including breast, lymph nodes and adrenal lesions in October of 2011. At last follow up May 2014, patient had no clinical or radiographic evidence of disease.