Timeline of treatment and demonstration of response. (a) Baseline chest CT scan prior to ipilimumab showed multiple subcutaneous, intramuscular, and pulmonary nodules (largest nodule indicated by white arrow). (b) Two months after completion of four treatments with ipilimumab, restaging PET scan showed decreased size of lung nodules, soft tissue and osseous involvement. (c) Repeat CT scan showed near radiographic resolution of lung nodule. (d) Timeline of described events (not to scale).